Can You Fail A Drug Test With Benadryl?


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Mark Henderson answered
Yes, Benadryl can cause a false positive result on a standard drugs test.

The active element contained in benadryl- diphenhydramine has been known to show up as similar to some substances which are searched for in a drug test, such as:

  • Benzodiazepines
  • PCP
  • Tricyclics
Can benadryl make you fail a drugs test?
  • Benadryl is an over-the-counter medicine which reduces the amount of the naturally-occurring chemical, histamine, in the body.
  • Histamine causes itching, watery eyes, runny nose, hives, rashes and the common cold.
  • It can also be used to alleviate the symptoms of a cough, induces sleep, and has even been used to treat the early onset of Parkinson's disease.
  • If you are pregnant, or have recently had a child, then always inform your doctor before you take Benadryl, as it could be harmful to a baby in the womb or passed through breast milk.
  • Benadryl first become publicly-available through prescription in 1946, after the medicine was invented by George Rieveschl a few years earlier.
If you are taking Benadryl and are expecting to be drug tested soon, then take the packet along to the screening and notify the technician.

They should then know that a false positive may be present on your test, and can account for the effects of Benadryl on the results.

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