The half life of Zopiclone (the time it takes for half of the drug to clear from your body) is 6 hours.
It typically takes 4-6 half lives for the drug to be totally cleared from the blood so 24-36 hours before it is totally out of your system.
Zopiclone is a treatment for insomnia. It is given in a low dose and only taken for a maximum of four weeks which reduces the chances of tolerance, dependance and withdrawal symptoms. Reducing your intake of the drug over this period may reduce the chances of these problems occurring.
You need to get a full nights sleep whilst taking these tablets, if your sleep is interrupted Zopiclone may cause memory problems.
Zopiclone is rapidly absorbed and things like gender, food or repetition of dose does not change the rate of that very much.