In most cases, Baclofen can leave your system within a day of taking it. However, there are some important things you need to know when you decide to stop taking a certain medication or substance:
Cleaning your system of Baclofen
If you have been on this drug for some time, you are advised not to come off it suddenly as it could cause side effects. You need to slowly decrease the dose over a period of weeks, and it is advisable to do this with the help of your doctor who will tell you how to slowly cut down and over what period you should do it.
The time it takes for your body to metabolise and secrete a drug so that half of it is cleared from your body is called a half life. It takes around 5 half lives for most drugs to clear your system so multiplying the drug's half life by 5 will tell you how long is needed for most drugs to clear your system.
The half life of Baclofen is 2-4 hours, so the drug should clear your system within 10-20 hours.